Saskatoon is the largest city in the Canadian province of Saskatchewan. It straddles a bend in the South Saskatchewan River in the central regi…Saskatoon is the largest city in the Canadian province of Saskatchewan. It straddles a bend in the South Saskatchewan River in the central region of the province. It is located along the Trans-Canada Yellowhead Highway, and has served as the cultural and economic hub of central Saskatchewan since its founding in 1882 as a Temperance colony.