Despite a wave of injuries to key position groups, San Francisco has persevered and is right in the thick of an ultra-competitive NFC West. Somewhat ironically, running back Christian McCaffrey has remained healthy throughout the season. The All-Pro leads the NFL in yards from scrimmage.

Brock Purdy hasn't suited up since late September because of a turf toe injury, but San Francisco 49ers head coach Kyle Shanahan said he doesn't expect the injury to keep Purdy out for the rest of the season.

The San Francisco 49ers can't catch a break with their receiving corps, and their top WR remains out to begin Week 10 action.

San Francisco 49ers running back Christian McCaffrey (23) stiff-arms New York Giants cornerback Andru Phillips (22) during the third quarter of an NFL football game, Sunday, Nov. 2, 2025, in East Rutherford, N.J. Credit: AP/Frank Franklin II

The Niners were fresh off a roster revamp, saying goodbye to nearly 20 players in the offseason, 15 of whom landed deals elsewhere worth up to a maximum of $341.5 million. In their place, the 49ers leaned into their youth, with an 11-man draft class and a free agent group that had no marquee players.

Mykel Williams is feared to have suffered a potential season-ending injury in San Francisco's win over the Giants.

Rams consultant suggested that 49ers quarterback Brock Purdy should attempt to "stabilize" his turf toe injury

The San Francisco 49ers have been aggressive at the trade deadline in past seasons, trading valuable draft picks for upgrades they believed could increase their chances of winning a Super Bowl. With the team holding a 6-3 record this year and in the thick of the playoff race,