Nucleation of branched actin filaments by Arp2/3 complex is tightly regulated to control actin assembly in cells. Arp2/3 complex activation involves conformational changes brought about by ATP, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, No. 3, [Part 2: Biological Sciences] (Mar., 1981), pp. 1346-1350 (5 pages) The Lymn-Taylor model for the ...

Actin filaments are protein fibers that make up the internal skeleton of the cell. As active elements of our cells, actin filaments support the cell's fusion, movement and are involved in many other ...

At the molecular level, muscle contraction is defined by myosin molecules pulling actin filaments. New electron cryomicroscopy images with unprecedented resolution taken by researchers at Osaka ...

One of the major proteins of the chicken intestinal microvillus is a calmodulin-binding protein of 105-110 kdaltons which has been tentatively identified as the bridge linking the microvillar filament ...

The dynamic processes that occur during the growth of actin, via polymerization, and the breakdown of actin both play significant roles in cellular mechanisms like migration and adhesion. Due to the ...

Myosin in muscles behaves in a unique way, which might explain why muscles have such strong contractile power. A cartoon showing the asymmetry in the weak binding between myosin and actin that biases ...

Cancer cells undergo physically constraining processes, such as intravasation, extravasation, and tissue infiltration, that lead to acute mechanical stress. How mechanical confinement rewires the ...

A recently identified bacterial protein, named BeeR, is contributing to the design of novel anticancer drug delivery systems. Researchers from King’s College London (UK) and the University of ...

A previously unknown protein in a family of bacteria found in soil and the human gut microbiome has been discovered – which could help drug delivery in cancer treatment. In a paper published in PNAS, ...

“We are answering fundamental questions of life that scientists have been trying to answer for several decades”, remarks Raunser. In eukaryotic cells, actin proteins are abundant and tend to join ...