Move over, amyloid, reactive astrocytes and activated microglia may be the main drivers of the Alzheimer’s disease pathological cascade. In the November 6 Nature Neuroscience, scientists led by Pedro ...

The mechanism of astrocytic autophagy plasticity plays a crucial role in AD. When the autophagy-regulating genes (LC3B and SQSTM1) in astrocytes are activated, Aβ is efficiently removed, which is ...

The potential effects of astrocyte dysfunction in neurodegenerative diseases are summarized in Figure 2. AD is characterized clinically by cognitive loss in two or more domains, including memory, ...

Cells feature an array of biological cascades to respond to stressors such as protein aggregates, viruses, and DNA damage. When these pathways are activated too much or for too long, things can go ...

Cedars-Sinai investigators have discovered a healing mechanism that could one day be harnessed to help treat patients with spinal cord injuries, stroke, and neurological conditions such as multiple ...