For years, researchers considered Alzheimer’s disease (AD) an amyloid beta and neuron-related condition. But having trained as a pathologist, Thomas Montine, who is now a neuropathology researcher at ...

While amyloid β plaques are hallmarks of Alzheimer’s disease (AD), recent research suggests that they aren’t the only players in the neurodegenerative disorder. Genome-wide association studies and RNA ...

Scientists have uncovered a microglial switch that transforms these immune cells from plaque-promoting to plaque-protective, offering a new path toward immunomodulatory treatments for Alzheimer’s ...

Ever since the discovery of AD risk-stoking variants of TREM2, the microglial receptor has given scientists seeking to nail down its function a run for their money. It binds many ligands, supports ...

Many people with Alzheimer’s notice their sense of smell isn’t as sharp as it used to be long before their memory declines. The underlying mechanisms responsible for this change have remained a ...