Macromolecular CSPs can report on conformational averaging between free and bound states, and so can be used to extract binding constants for (weakly binding) ligands, as shown in Figure 2B. The ...

In a study published in Nature Methods, a research group developed a highly sensitive proteomics method called peptide-centric local stability assay (PELSA), which enables the simultaneous ...

A team of scientists has created a powerful new method for generating protein drugs. Using computers, they designed molecules that can target important proteins in the body, such as the insulin ...

A deep-learning tool that accurately predicts metal-binding sites in proteins for a wide range of metal ions has been ...

A pair of recent papers helps clear up a longstanding mystery about the enzyme particulate methane monooxygenase (pMMO). The enzyme sits in the membranes of bacteria that consume methane as their main ...

The term biotinylation refers to the process of binding biotin to either a protein or a nucleic acid, or in some cases to another type of molecule. An antibody is one of these potential targets, a ...