Bone formation and deposition are initiated by sensory nerve infiltration in adaptive bone remodeling. Here, we focused on the role of Semaphorin 3A (Sema3A), expressed by sensory nerves, in ...

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts. An ...

Osteoporosis is a common disorder, especially in the elderly, characterized by bone loss and increased fracture risk. Treatments target abnormal osteoclast activity but face adherence issues. The ...

A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering potential therapeutic applications for osteoporosis. NELL2 promotes ...

New research uncovers how the Clec14a protein in capillary endothelial cells controls bone growth and maturation, revealing a key mechanism in skeletal development. Study: Type-H endothelial cell ...