DNA is often seen as the blueprint of life—carrying the code to govern the development and traits of an organism—but “there are things beyond the DNA sequence,” says Xiaoqi Feng, a plant geneticist at ...

Under physiological conditions, most double-stranded nucleic acids adopt right-handed helical conformations such as B-DNA or A-RNA. However, under specific cellular stresses, nucleic acids can ...

CRISPR—Clustered Regularly Interspaced Short Palindromic Repeats—is the microbial world’s answer to adaptive immunity. Bacteria don’t generate antibodies when they are invaded by a pathogen and then ...

A research group led by the University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a ...

Researchers at the University of Bristol have caught DNA-copying enzymes generating long stretches of genetic code without any template to guide them, a behavior the team calls “doodling.” Published ...

Thus, ArcS is an unprecedented tRNA modification enzyme that can act on a nucleoside as the substrate. With the development of mRNA vaccines for COVID-19, modified nucleosides like pseudouridine and 1 ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by researchers at Goethe University Frankfurt, part of the Rhine-Main University ...

As genome editing therapies move through clinical trials to regulatory approval, scientists continue the quest for the holy ...