RIF1 is a multifunctional protein that regulates DNA replication and repair. RIF1-deficient cells are hypersensitive to DNA replication stress. Of the two alternatively spliced RIF1 isoforms, called ...

A new review in the Journal of Translational Medicine consolidates how the replication-initiation protein ORC1 safeguards ...

Every day, billions of cells in your body divide, helping to replace old and injured cells with new ones. And each time this happens, your entire genetic library—your genome, which totals more than 3 ...

DNA methylation is an epigenetic modification in which a methyl group is added to a DNA base without changing the underlying DNA sequence. In mammals, the best-known form is 5-methylcytosine (5mC), ...

Researchers developed a photocatalytic method to capture proteins near G-quadruplex DNA, identifying hexokinase-1 as a strong ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy);(2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 ...

Understanding gene regulation may be key to interpreting human disease genetics. Genes are regulated in part by stretches of DNA called enhancers, which define when, where and how strongly each gene ...

This article predates the current owners of Science Blog. It has not been reviewed under the current editorial process and is kept as part of the archive. Sascha Duttke, an assistant professor in the ...

Every cell type in the human body carries the same approximately 3.2 billion base pairs of DNA, yet a liver cell behaves nothing like a neuron. The epigenome explains this difference: in each cell, ...

Antibodies, also known as immunoglobulins, are specialized proteins that are generated by the immune system to identify and neutralize pathogens. They circulate throughout the body to monitor invading ...