Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression. Scientists have now developed a way to silence that cellular noise, ...

Life’s instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins. Scientists ...

A bacterial protein helps to stop transcription -- the process of making RNA copies of DNA to carry out the functions of the cell -- by causing the cellular machinery that transcribes the DNA to pause ...

LMU scientists have shown that a fundamental process of life works differently than previously assumed. The basic process of life, known as transcription, is the process by which the genetic ...

As imaging tools continue to get more sophisticated, researchers have been able to actually watch biological processes as they are happening in live cells. Scientists have now visualized loops of DNA ...

When the molecular machinery in our cells gets to work transcribing the genetic information encoded in DNA into messenger RNA (mRNA), it pauses shortly after starting. Known as promoter-proximal ...

Researchers developed e2MPRA, a high-throughput technique that simultaneously measures cis-regulatory element activity and epigenetic state. By analyzing thousands of sequences, the method showed that ...

To support drug discovery, a new study has revealed fundamental features of the transcription cycle in the bacteria that causes tuberculosis.

Study in Genes & Development has shown that blocking the transcriptional regulator p300 forces tumour cells into lethal protein stress, re-sensitising chemotherapy-resistant cancers without an ...