As common as depression is—about one person in 10 experiences depression in any given year—it still eludes complete understanding. There does not seem to be a single cause; rather many factors ...

A large international study led by researchers at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, shows that major depressive disorder (MDD) not only increases risk ...

The early pathophysiology of depression is poorly understood. We elucidated the decadal temporal evolution of plasma proteomic alterations before depression diagnosis and evaluated their associations ...

The core experiences of depression — changes in energy, activity, thinking, and mood — have been described for more than 10,000 years. The word “depression” has been used for about 350 years. Given ...

MicroRNAs are pivotal regulators of gene expression in the brain, orchestrating the fine-tuning of neural circuits that underlie mood and cognition. In major depressive disorder, dynamic alterations ...

The TO_AITION project, completed this month (December 2025), has been investigating the biological causes of inflammation linking cardiovascular diseases (CVD) and depression, and has used a wide ...

Avolition refers to a severe reduction in self-initiated drive that makes starting or finishing everyday tasks feel overwhelming or impossible, even when you recognize their importance or want to ...

Childhood depression is a serious mental health condition that can affect children''s emotional well-being and daily functioning. While it's normal for children to experience sadness and mood changes ...

Feeling persistently sad, exhausted, or hopeless doesn’t always mean you’re dealing with clinical depression. Several medical conditions create nearly identical symptoms that can fool both patients ...

As common as depression is—about one person in 10 experiences depression in any given year—it still eludes complete understanding. The trigger for depression can be almost any negative experience or ...