New technology enables the insertion of a large segment of DNA into a genome, potentially expanding gene therapy treatment ...

A novel genome editing technique, NICER, is based on the creation of multiple nicks in single DNA strands by nickase. The method can correct heterozygous mutations using two mechanisms: multiple nicks ...

PHILADELPHIA— A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods. The approach ...

CRISPR-Cas9 is widely used to edit the genome by studying genes of interest and modifying disease-associated genes. However, this process is associated with side effects including unwanted mutations ...

Researchers have opened a transformative chapter in agricultural biotechnology by unveiling virus-induced genome editing (VIGE) techniques for Solanaceous crops, a group that includes tomatoes, ...

A powerful new approach for the precise, flexible modification of a broad class of chemical compounds called bicyclic aza-arenes—which are commonly used to build drug molecules—has been developed. The ...

Scientists have developed a 'prime assembly' genome editing technique capable of inserting large DNA segments, potentially replacing entire faulty genes and correcting up to 1,000 mutations in one ...