Nature

Inhibition of farnesyl pyrophosphate synthase prevents norepinephrine–induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive rats

Both norepinephrine (NE) and connective tissue growth factor (CTGF) contribute to vascular fibrosis during hypertension. Recent studies indicate that farnesyl pyrophosphate synthase (FPPS) plays an ...
BioWorld

Items Tagged with 'farnesyl pyrophosphate'

Under certain circumstances, a normally innocuous key molecular intermediate of regular cell metabolism, farnesyl pyrophosphate, can trigger neuronal lysis and cell death, according to a study led by ...
JSTOR Daily

Clomazone Does Not Inhibit the Conversion of Isopentenyl Pyrophosphate to Geranyl, Farnesyl, or Geranylgeranyl Pyrophosphate In vitro

This is a preview. Log in through your library . Abstract Clomazone, an herbicide that reduces the levels of leaf carotenoids and chlorophylls, is thought to act by inhibiting isopentenyl ...
C&EN

Drug Design Leads To Desired Enzyme Inhibitors

A research team at the Novartis Institutes for Biomedical Research, in Basel, Switzerland, has discovered the first potent non-bisphosphonate inhibitors of farnesyl pyrophosphate synthase (FPPS), an ...
Nature

Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase

Post-translational addition of isoprenoids is an essential modification of many proteins involved in signaling pathways controlling cell growth, differentiation, cytoskeletal rearrangement and ...