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RNA technology 'hacks' into phage replication, offering new insights into molecular interactions

Bacteriophages, or phages for short, are viruses that infect bacteria. Using phages therapeutically could be very useful in fighting antibiotic-resistant pathogens, but the molecular interactions ...
GEN

Phage Structure Revealed by CryoEM

For the first time, researchers at the University of Exeter, in collaboration with Massey University and Nanophage Technologies, have mapped out what a commonly-used form of phage looks like. Their ...
CU Boulder News & Events

Bacterial cGAS-like enzymes produce 2′,3′-cGAMP to activate an ion channel that restricts phage replication

BioRxiv (2023) PubMed PMID: 37546940; PubMed Central PMCID: PMC10402079. The mammalian innate immune system uses cyclic GMP–AMP synthase (cGAS) to synthesize the cyclic dinucleotide 2′,3′-cGAMP during ...
JSTOR Daily

Phage φ29 Protein p56 Prevents Viral DNA Replication Impairment Caused by Uracil Excision Activity of Uracil-DNA Glycosylase

Protein p56 encoded by the Bacillus subtilis phage φ29 inhibits host uracil-DNA glycosylase (UDG) activity. In previous studies, we suggested that this inhibition is likely a defense mechanism ...