New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...
Recent years have seen major advances in understanding the structure-function relationships of G protein-coupled receptors (GPCRs). This large superfamily of transmembrane receptors comprises over 800 ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 28 (July 13, 2021), pp. 1-10 (10 pages) The evolutionary expansion of G protein-coupled receptors (GPCRs) ...
G protein-coupled receptors (GPCRs) represent a diverse group of signaling proteins and are involved in a wide variety of physiological processes. Of particular importance to the pharmaceutical ...
A group of researchers has identified the cause of a 'short-circuit' in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases and could lead to development ...
GPCR dynamics, shown in purple as the human A 2A receptor, and elegant modifications in activation pathways (allostery) indicated by the blue arrow, are critical for enabling GPCRs to bind to multiple ...
The GPCR-targeting therapies market is expected to grow significantly in the coming years. This is due to the increasing number of patients who are being diagnosed with cancer, the growing awareness ...
Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all phosphoevents ...
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