Hypothalamic damage disrupts hunger and satiety regulation, causing rapid weight gain, which often responds poorly to ...

The phase III TRANSCEND trial showed that treatment with setmelanotide (Imcivree), a melanocortin-4 receptor (MC4R) agonist, ...

MC4R pathway restoration with daily subcutaneous setmelanotide achieved a −16.5% least-squares mean BMI change versus +3.3% with placebo at 52 weeks (P < .001). Clinically relevant response rates ...

Cambridge scientists have shown that the hypothalamus, a key region of the brain involved in controlling appetite, is different in the brains of people who are overweight and people with obesity when ...

Phase III data supported setmelanotide's recent label expansion in acquired hypothalamic o ...

Compared to sugar, consuming sucralose—a widely used sugar substitute—increases activity in the hypothalamus, a brain region that regulates appetite and body weight, according to a new USC study.

Estrogens are known for their role in reproduction, but a new study reveals that neuroestrogens -- estrogens produced in the brain -- play a key role in appetite regulation. These brain-made hormones ...

The hypothalamus is a small but critical region at the base of the brain that controls the autonomic nervous system, regulates body temperature, signals hunger and thirst, exerts hormonal control over ...

When Finn Rudmann was 6, he had brain surgery. For years after, he felt uncontrollable hunger that never went away. The rare brain condition made the Spokane boy feel like he was starving no ...

Researchers from the lab of Richard Simerly have uncovered the first example of activity-dependent development of hypothalamic neural circuitry. The work also suggests a novel role for the hunger ...