Mutant Brown-Norway-Katholiek (muBN-Ka) rats are capable of producing kininogens in the liver, but cannot release them into the bloodstream, because of the point mutation of Ala163 to Thr in the ...

Overexpression of human tissue kallikrein (HK), mediated by recombinant adeno-associated virus (rAAV), decreased blood pressure in spontaneous hypertensive rats (SHRs) and reduced injury to the heart, ...

Scientific team found a new metabolism regulation system for the brown adipose tissue using the kallikrein-kinin hormonal system, so far related to the physiology of the renal and cardiovascular ...

Real-world practice patterns in treatment of metastatic breast cancer in Washington State. PI3Kγδ inhibitor combined radiation enhances the antitumor immune effect of PD-1 blockade in syngenic triple ...

Dr. Schmaier’s major investigative work is on the vascular biology of the plasma kallikrein/kinin (KKS) and rennin angiotensin (RAS) systems. The Schmaier laboratory recognized that the endothelial ...

CAMBRIDGE, Mass. & SALISBURY, England--(BUSINESS WIRE)--KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on the discovery, development, and ...

Blood–brain barrier (BBB) disruption and transendothelial trafficking of immune cells into the central nervous system (CNS) are pathophysiological hallmarks of neuroinflammatory disorders like ...

Poseida Therapeutics’ gene therapy for hereditary angioedema (HAE) reduced kallikrein protein activity in a mouse model of the disease and edited a gene in the livers of nonhuman primates, the company ...

A recombinant formulation of human tissue kallikrein (KLK1) is safe and tolerable in patients with acute ischemic stroke, phase 2 results suggest. KLK1 is an endogenous vasoactive serine protease and ...

Hereditary angioedema is a life-threatening illness caused by mutations in the gene encoding C1 inhibitor (also called C1 esterase inhibitor) that lead to overactivation of the kallikrein–bradykinin ...