Dietary sodium restriction is a key determinant of diuretic efficacy. When dietary sodium intake is high, postdiuretic sodium retention compensates almost entirely for the loop-diuretic-induced sodium ...

Loop diuretics are widely used, especially in patients with hypertension or heart failure plus renal dysfunction. Such patients are particularly susceptible to untoward drug effects. It is, therefore, ...

Most accepted pharmacologic treatments for heart failure are supported by evidence from large clinical trials. In contrast, evidence from large, well-controlled clinical trials to guide the use of ...

Semaglutide reduces the need for loop diuretic use and dose, and has positive effects on symptoms, physical limitations, and body weight in patients with heart failure with preserved ejection fraction ...

Medically reviewed by Alex Yampolsky, PharmD Key Takeaways Alpha-blockers and Alpha-2 agonists are not recommended as first-choice treatment for high blood pressure.Beta-blockers can worsen asthma ...

Finerenone reduced heart failure events and cardiovascular deaths in patients with HFmrEF or HFpEF when used with diuretics. The study found finerenone reduced hypokalemia risk but increased ...