Osteocalcin is necessary and sufficient to correct age-related decline in cognitive function in mice Mouse maternal osteocalcin contributes to brain development and the acquisition of cognitive ...

“Circulating osteocalcin levels increase markedly during endurance exercise in mice and humans,” explains author Gerard Karsenty. This observation indicated that osteocalcin might be involved in the ...

Bones are more than just the scaffolding for our body lumps. Bones are rigid organs filled with a honeycomb-like matrix, and while they do protect our internal organs, they also secret several ...

In the mid-nineteen-nineties, a young French geneticist and physician named Gerard Karsenty became curious about a mysterious protein, called osteocalcin, that is found at high concentrations in the ...

Osteocalcin (OCN), a protein produced by bone-forming cells, has traditionally been studied for its role in bone mineralization. In recent years, its undercarboxylated form (Glu-OCN) has gained ...

An anxious public speaker and a sky diver with vertigo have more in common than stress. But to really know what they share, you’d have to look beneath the surface — at their bones. In September 2019, ...

Experiments in mice and observations in humans have suggested the bone protein osteocalcin acts as a hormone regulating, among other things, metabolism, fertility, exercise capacity and acute stress.

CI: Confidence interval; HbA1c: Glycated hemoglobin; I: Interventional study; IR: Insulin resistance; L: Longitudinal study; OR: Odds ratio; TOC: Total osteocalcin; X ...

Scientists are examining what is really behind the human fight-or-flight response—a bodily reaction to mental and physical stressors that prepares us either to stay and combat the threat (fight) or to ...

Glu-OCN is secreted by osteoblasts and then undergoes γ-carboxylation at glutamic acid residues at positions 17, 21, and 24, a reaction catalyzed by γ-glutamyl carboxylase (GGCX) in a vitamin ...