Xiaoyan Liu, Weidi Xiao, Yanan Zhang, Sandra E. Wiley, Tao Zuo, Yingying Zheng, Natalie Chen, Lu Chen, Xiaorong Wang, Yawen Zheng, Lan Huang, Shixian Lin, Anne N ...

Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease ...

The proteasome is a fundamental component of eukaryotic cellular machinery, responsible for the precise degradation of intracellular proteins. By orchestrating the breakdown of both misfolded and ...

The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but ...

At the recent Celebration of Native Mass Spectrometry in Oxford, we caught up with Michal Sharon to talk about her research and the fascinating evolutionary history of the 20S proteasome. Would you ...

Many therapeutic targets escape druggability by mysterious molecular motions that cannot be precisely visualized. This ‘dark-world’ reality is particularly augmented in the ubiquitin-proteasome system ...

Massachusetts General Hospital (MGH) investigators have discovered the mechanism by which cells sense dysfunction of the proteasome - a cellular component that degrades unneeded or defective proteins ...

The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but ...

Reporting unexpected processes, chemists say they have discovered how an enzyme known as UCH37 regulates a cell's waste management system. In a new paper with results that senior author Eric Strieter ...

Booster Therapeutics Awarded Grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to Advance New Class of Proteasome Activator Medicines Towards First-in-Human Phase 1 Study ...