A new technique based on the Staudinger ligation has enabled researchers to conduct a broad analysis of cellular targets of protein farnesylation, with potential implications for future proteomic ...

Despite the success of protein farnesyltransferase inhibitors (FTIs) in the treatment of certain malignancies, their mode of action is incompletely understood. Dissecting the molecular pathways ...

Researchers identify metabolic pathway essential for embryo development, thus extending knowledge of how embryos form and how to develop a safer drug regimen for pregnant women Tokyo - Much has been ...

Schematic diagram of mouse embryonic development on the indicated days. Bottom: The mevalonate pathway produces farnesyl diphosphate for cholesterol synthesis, protein geranylgeranylation and protein ...

A recently developed proteomics strategy, designated tagging-via-substrate (TAS) approach, is described for the detection and proteomic analysis of farnesylated proteins. TAS technology involves ...

Researchers showed that the mevalonate pathway is essential for embryonic development by promoting primitive streak formation, a key landmark for establishing embryo symmetry and gastrulation. The ...