Protein folding raises some of biology's greatest theoretical challenges. It also lies at the root of many diseases. For example, the fundamental question of whether a protein's final tertiary ...

Scientists have found a new way to predict how proteins change their shape when they function, which is important for understanding how they work in living systems. While recent artificial ...

Although they are much weaker than the preeminent "covalent" chemical bonds that bind atoms in biological molecules, hydrogen bonds are known to occur at key points along the central "backbone" ...

Whereas most proteins fit the "two-state" model of exponential folding kinetics, the molecules of PGK followed a different pattern to reach a fully folded state. This new pattern was described as ...

Numerous BYU students, including Mikaila Sass (pictured), worked with Dr. Willardson in his lab on this discovery. The human body heavily relies on protein molecules for proper functioning. Protein ...

Researchers have developed a method to evaluate the folding stability of a million proteins simultaneously. DNA libraries were used to generate protein -- DNA complexes that were treated with enzymes ...

For those outside the chemistry cognoscenti, the announcement might have seemed little more than researchers patting each other on the back. But the question of protein folding had plagued scientists ...

Just as a misshapen key can't open a lock, the proteins in our cells need to have the correct 3D shape to function properly. And defects in a protein's structure can cause diseases. Proteins are ...

Researchers from Northwestern University and the Institute for Industrial Science at the University of Tokyo say they have developed a new high-throughput approach known as cDNA display proteolysis to ...

Edited by: James Kling K.A. Dill, S. Bromberg, K.Z. Yue, K.M. Fiebig, D.P. Yee, P.D. Thomas, H.S. Chan, "Principles of protein-folding-a perspective from simple exact ...