Intracellular protein editing. Credit: Science (2025). DOI: 10.1126/science.adr5499. https://www.science.org/doi/10.1126/science.adr5499 University of Pennsylvania ...

Understanding how proteins behave in living systems is central to biology. Yet, for decades, researchers have relied on overexpression models or antibody-based detection methods that can distort the ...

Small but powerful: Ubiquitin controls the lifespan and distribution of proteins in the cell, but it can also determine their shape, function, or interactions with other cellular components. Ubiquitin ...

Researchers have elucidated key steps in the ubiquitin tagging of the mutated huntingtin protein, providing hope for future therapies. There is no known cure for Huntington's disease. A genetic ...

New research from scientists at the University of Birmingham and other institutions describes a method of counting labeled proteins in living cells dubbed Protein-tag Degree of Labeling (PRoDOL) that ...

Proteins, one of the smallest building blocks of life on Earth, hold promise for answering some of biology's biggest ...

His-tagged proteins underpin research in structural biology, test development, and drug development. Their small tag enables easy purification and rapid construct iteration. When screening many ...

Bioluminescent assays are essential tools for tracking protein activity, cell signaling pathways and cellular dynamics. These assays provide high sensitivity, low background noise, and flexibility for ...