Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of erythrocyte pyruvate ...

Over the past decade, small molecule kinase inhibitors have emerged as promising therapeutics, particularly in oncology. Through data that has emerged during this period, it has become increasingly ...

Kinases catalyze the transfer of the γ-phosphate from adenosine 5´-triphosphate (ATP) to proteins, lipids, sugars, or other acceptors. This process, termed phosphorylation, forms the cornerstone of ...

In the continuously changing environment of drug development and molecular biology, sensitive and high-throughput kinase activity monitoring remains a key component of target validation and inhibitor ...