IN 1962, when David R. Davies was in his 30s, he and two coworkers at the National Institutes of Health proposed that short, guanine-rich stretches of DNA could assume unusual structures. On the basis ...

The direct observation and quantification of G-quadruplex structures formed from DNA in human cells during the cell cycle demonstrate the biological importance of these structures and point towards ...

DNA, the genetic material compacted in chromosomes, stores information to regulate all the cell processes in the body. Two decades ago, in addition to the widely known Watson-Crick double helix model ...

There is no more iconic image in biology than that of DNA's double-stranded helix, which coils and supercoils on itself to form dense chromosomes. But a quite different, square-shaped type of DNA ...

Researchers have discovered how certain proteins can attach to special structures in RNA, called G-quadruplexes. Additionally, they have developed computational tools capable of predicting these ...

Most women with ovarian cancer respond very well to chemotherapy at first – but in 70% of cases the cancer grows back. And although many patients will respond to chemotherapy a second or third time, ...

A small fluorescent molecule has shed new light on knots of DNA thought to play a role in regulating how genes are switched on and off. DNA is typically arranged in a double helix, where two strands ...

WEST LAFAYETTE, Ind. – A gene called MYC has become one of the hottest targets for cancer researchers around the world. MYC is known to drive tumor growth in nearly all cancer types – but successfully ...