Reactive systems synthesis is a rapidly evolving discipline that focuses on the automated construction of systems designed to interact continuously with complex and often unpredictable environments.

It’s a common enough scenario in many synthesis labs: you know what starting material you have, and you know what product you need but not quite what reaction conditions will get you there. Unless you ...

Process development is key to identifying the optimal parameters used for synthesis, manufacturing, and stability testing. It is also key to generating the data required for the filing processes of ...

In contrast to conventional organic synthesis, mechanochemistry does not use solvents that eventually become industrial wastes. Thus, mechanochemistry is environmentally friendly and enables us to ...

Because ketones are widespread in organic molecules, chemists are eager to develop new reactions that use them to form chemical bonds. One challenging reaction is the one-electron reduction of ketones ...

Reactive intermediates, such as carbocations, carbanions, radicals, carbenes, nitrenes, and organometallic species, play a crucial role in organic syntheses, yet their transient nature makes them ...

Scientists at Scripps Research have used rapid alternating current (AC) to selectively reduce carbonyl groups (J. Am. Chem. Soc. 2021, DOI: 10.1021/jacs.1c06572). The technique avoids side reactions ...

This module explores the synthesis of amines with a focus on the reductive amination reaction. Numerous examples from the discovery and commercial manufacturing of pharmaceuticals are included. After ...

The search for a new ammonia-synthesis method has now driven research and development work underground, literally. Addis ...