Figure 1: ABPP of complex proteomes with the serine hydrolase–directed probe FP-rhodamine. Figure 2: Identification and characterization of serine hydrolase targets of the inhibitor library. Figure 3: ...

Small-molecule inhibitors of enzymes can, in principle, treat human disease. But first, researchers must confirm that an inhibitor actually binds its enzyme target in animal experiments. This can be a ...

Researchers describe slow-binding inhibition of cholinesterases and present their pharmacological advantages over classical reversible inhibitors (e.g. long target-residence times, resulting in ...

As scientists race to discover new and effective antiviral drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many novel approaches are being utilized. Now, a new study ...

Reversible inhibition of enzyme, an activity in which the inhibiting molecular entity (often a small chemical called ligand or inhibitor) can associate and dissociate from the protein's binding site, ...