Biological samples can be highly susceptible to changes over time, which often occur when they are removed from deep refrigeration. Degraded samples can produce spurious results in research. To ...

Samples used in biomedical research are often collected over years, in some cases from subjects that may have died and thus cannot be retrieved in any way. The value of these samples is priceless.

Research participants often do not represent the general population. Systematic exclusion of particular groups from research limits the generalizability of research findings and perpetuates health ...

Scientific research has a long history of using well-established, well documented, and validated methods for the design, conduct, and analysis of clinical trials. A study design that is considered ...

Biological samples are vital to disease research, but they often comprise highly sensitive materials. Living cells, for example, are susceptible to minor environmental shifts, while nucleic acids can ...

Findings from the Systematizing Confidence in Open Research and Evidence (SCORE) program—a collaborative effort involving 865 researchers—have been published in Nature as a collection of three papers ...