Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context. In musculoskeletal ...

Single-cell RNA transcriptomics allows researchers to broadly profile the gene expression of individual cells in a particular tissue. This technique has allowed researchers to identify new subsets of ...

Challenges and Prospects. Challenges and prospects faced by spatial transcriptomics itself and its application to the musculoskeletal system. AI Artificial intelligence, FFPE Formalin fixed and ...

The brain is an extremely heterogeneous tissue. Within one small piece, there are neurons transmitting information, oligodendrocytes and astrocytes acting as support cells and microglia functioning as ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

Spatial biology is reshaping how researchers study cancer by revealing the architecture and complexity of tumors in extraordinary detail. Through techniques that combine protein- and gene-level ...

Tumors contain many different types of cells organized in complex spatial patterns that can influence how the disease progresses. Because of this, it is hard to predict how a tumor will develop and ...

Understanding which cells within a tumor will go on to form metastases remains one of the major challenges in cancer research ...

A whole developing wheat spike, 1mm scale. The blue represents fluorescent staining for DNA withing the nuclei. There are different coloured spots showing gene expression detected using the probes in ...