This is a preview. Log in through your library . Abstract Angiogenesis, the formation of new blood vessels, is tightly regulated by gene transcriptional programs. Yin Ying 1 (YY1) is a ubiquitously ...

Researchers report new organ-on-a-chip technology to observe sprouting angiogenesis from a single blood vessel. VEGF stimulated new capillaries from the single vessel by activating NOTCH signaling, ...

During sprouting angiogenesis, tip cells are selected from the endothelial cells of existing vessels to pave the way for new blood vessels. Although a gradient of vascular endothelial growth factor A ...

Blood vessels are the body’s essential architecture that exists in order to nurture cells with sufficient nutrients and oxygen. Angiogenesis, or the formation of new blood vessels, is of great ...

Angiogenesis is a complex morphogenetic process whereby endothelial cells from existing vessels invade as multicellular sprouts to form new vessels. Here, we have engineered a unique organotypic model ...

To provide sufficient oxygen to tissues and organs within the body, blood vessels need to sprout new offshoots to form a widespread blood supply network, much like the trunk, branches, and twigs of a ...

Blood vessels are the roads and highways of the cardiovascular system, carrying oxygenated blood cells, nutrients, and immune cells in and out of the heart, brain, and other various organs in the body ...

What is "normal" blood vessel growth? The branching network of blood vessels in our bodies is vast. Lined up end-to-end, the blood vessels in just one adult could encircle the Earth twice. While it's ...

For months, Sabrina Staples stared at a silicone chip no bigger than a postage stamp, trying to coax cells into doing something remarkable. But every time she loaded her delicate microfluidic device ...

Researchers at the Institute of Industrial Science (IIS), the University of Tokyo, CNRS and INSERM, report a new organ-on-a-chip technology for the study of blood vessel formation and drugs targeting ...

'Merlin' serves as a gatekeeper in new blood vessel formation. Merlin suppresses internalization of VEGFR2, which is important for the formation of 'tip' endothelial cells. Blood vessels are the ...