Frontiers

Adverse Cardiovascular and Systemic Effects of Sedative Infusions in Critically Ill Children

In pediatric critical care, the use of intravenous sedative infusions is a cornerstone of managing mechanically ventilated ...
Medscape

Systemic, Not Just Local, Inflammation Implicated as a Driver of Alopecia Areata

NEW YORK — Alopecia areata, an autoimmune condition, is known to be driven by immune cell infiltration and upregulated cytokines that attack hair follicles, but the importance of systemic — not just ...
ascopubs.org

Metastasis-Directed Stereotactic Body Radiation Therapy in Oligometastatic and Oligoprogressive Solid Malignancy: Outcomes and Effect on Systemic Treatment

The primary end points were FISST and local control (LC) rates of lesions that received SBRT. The secondary end point was overall survival (OS) after SBRT. To calculate FISST, event was defined as the ...
Morningstar

Coya Therapeutics' COYA 303 Shows Promising Central Nervous System (CNS) Anti-inflammatory Effects and Systemic Regulatory T Cell (Treg) Enhancing Effects in a Preclinical ...

COYA 303 is an investigational proprietary combination of LD-IL-2 and GLP-1RA for subcutaneous administration, under development for the treatment of diseases, including Alzheimer's Disease, driven by ...
ascopubs.org

Effect of anti CTLA-4 and PD-1 monoclonal antibodies on systemic SDF-1 and galectin-3 levels through NLRP3 and MyD-88 pathways in preclinical models.

Molecular predictors and mechanisms of immune checkpoint inhibitor-induced myocarditis: A case-control study with translational correlates. Predictive factors for cardiac events following concurrent ...