THE chordae tendineae serve an essential anchoring function in the mechanics of mitral-valve closure during ventricular systole. Rupture of one or more of these fibrous structures usually leads to ...
Mitral-valve replacement was performed in five patients with ruptured papillary muscle secondary to myocardial infarction. In each case severe mitral regurgitation was suggested by the sudden ...
Figure 1: Myocardial infarction activates IRF3-dependent signaling. Figure 3: Self-DNA is the dominant myocardial infarction–induced IRF3-activating DAMP. To determine whether ischemic injury disrupts ...
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