Journal of Nuclear Medicine

The Role of Amyloid-β and Tau PET in the New Era of Alzheimer Disease Therapies

The advent of amyloid-β (Aβ) and tau PET imaging has revolutionized Alzheimer disease (AD) research, enabling in vivo ...
Journal of Nuclear Medicine

Worldwide Potential of Radiotheranostics and the Challenges Faced by Developing Countries

Radiotheranostics refers to dual diagnostic–therapeutic capacity that allows for precision medicine at an unprecedented level, reducing collateral toxicity and improving patient outcomes ([1][1]). In ...
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Designed Ankyrin Repeat Protein–Mediated Peptide Nucleic Acid–Based Pretargeting: A Proof-of-Principle Study

Journal of Nuclear Medicine May 2025, jnumed.125.269533; DOI: https://doi.org/10.2967/jnumed.125.269533 ...
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First-in-Humans Study of

Good-manufacturing-practice–grade precursor DOTA-Siglec-9 was obtained from ABX Advanced Biomedical Compounds GmbH. All other reagents were purchased from commercial suppliers and were either ...
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Fast Spiral SPECT with Stationary γ-Cameras and Focusing Pinholes

SPECT is used to quantitatively and visually assess the distribution of radioactive biologic markers (tracers) in vivo in order to, for example, study animal models of disease and test new ...
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First-in-Human PET Imaging of Prostate Cancer Using

Journal of Nuclear Medicine November 2025, jnumed.125.270703; DOI: https://doi.org/10.2967/jnumed.125.270703 ...
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Tumor Lysis Syndrome: A Rare but Serious Complication of Radioligand Therapies

Tumor lysis syndrome (TLS), an oncometabolic emergency described in highly proliferating cancers such as lymphoma or leukemia, can occur spontaneously or after initiation of cytotoxic treatment such ...
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Validation of 2- 18 F-Fluorodeoxysorbitol as a Potential Radiopharmaceutical for Imaging Bacterial Infection in the Lung

2-18F-fluorodeoxysorbitol (18F-FDS) has been shown to be a promising agent with high selectivity and sensitivity in imaging bacterial infection. The objective of our study was to validate 18F-FDS as a ...
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PSMA-Directed PET/MRI Enables Noninvasive Diagnosis and Prognosis in Patients with Increased PSA Levels: Results from the Prospective Randomized RAPID Trial

Journal of Nuclear Medicine November 2025, jnumed.125.270404; DOI: https://doi.org/10.2967/jnumed.125.270404 ...
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Combination of 5-Fluorouracil with Epigenetic Modifiers Induces Radiosensitization, Somatostatin Receptor 2 Expression, and Radioligand Binding in Neuroendocrine Tumor Cells In ...

Neuroendocrine tumors (NETs) frequently form distant metastases and require systemic treatment (1). An established treatment option in advanced NETs is peptide receptor radionuclide therapy (PRRT) ...
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GLUT1 Expression in Tissue and

For staging of cancer patients, 18F-FDG PET imaging has been applied for about a decade. It is generally accepted that imaging the metabolic activity of tumor tissue provides more sensitive and more ...
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Prostate-Specific Membrane Antigen Ligands for Imaging and Therapy

The prostate-specific membrane antigen (PSMA) is highly expressed on most prostate cancer (PC) cells. Therefore, the targeting of PSMA has become increasingly important over the last decade.