For years, researchers considered Alzheimer’s disease (AD) an amyloid beta and neuron-related condition. But having trained as a pathologist, Thomas Montine, who is now a neuropathology researcher at ...

While amyloid β plaques are hallmarks of Alzheimer’s disease (AD), recent research suggests that they aren’t the only players in the neurodegenerative disorder. Genome-wide association studies and RNA ...

Scientists have uncovered a microglial switch that transforms these immune cells from plaque-promoting to plaque-protective, offering a new path toward immunomodulatory treatments for Alzheimer’s ...

When microglia wind up with a belly full of lipid droplets, it’s a sign that the cells are rallying, perhaps in vain, to a neurodegenerative threat. But according to a study published July 10 in Cell ...

Many people with Alzheimer’s notice their sense of smell isn’t as sharp as it used to be long before their memory declines. The underlying mechanisms responsible for this change have remained a ...

The timeline of microglia replacement evolution and its technical preparation in the pre-replacement era is summarized in this figure. Tiny charming immune cells called microglia protect the central ...