Super-enhancers in cancer cells trigger DNA breaks and error-prone repair cycles

A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...
News-Medical.Net on MSN

Super-enhancers: Cancer's double-edged sword of growth and DNA damage

New study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...
RMD Open

RA-risk synovium exhibits DNA damage coupled with impaired DNA repair in fibroblasts

Objectives Understanding the molecular changes in the preclinical synovium is crucial for identifying factors that drive arthritis development. Persistent DNA damage in tissues is known to drive a ...

Scientists reveal splicing-based mechanism driving therapy resistance in pediatric acute myeloid leukemia

Pediatric acute myeloid leukemia (AML) is one of the most common acute leukemias in children. While treatment outcomes have ...