Microglial activation is a determining factor that allows amyloid-beta accumulation to drive reactive astrogliosis, amplifying inflammatory responses in the brain. This was the conclusion of a study ...

Tiny immune cells called microglia protect the central nervous system (CNS) in a multitude of ways: They provide innate immunity, shape neurodevelopment, maintain homeostasis and modulate neurological ...

Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an ...

Alzheimer's disease (AD) is a highly debilitating neurodegenerative disease characterized by the progressive loss of memory and decline of mental functions. Earlier research has uncovered some of the ...

1 Center for Alternatives to Animal Testing, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States 2 Department ...

Add Yahoo as a preferred source to see more of our stories on Google. Microglial receptor ADGRG1 helps immune cells eat amyloid plaques and may offer new hope for Alzheimer's treatment. (CREDIT: ...

When microglia wind up with a belly full of lipid droplets, it’s a sign that the cells are rallying, perhaps in vain, to a neurodegenerative threat. But according to a study published July 10 in Cell ...

It’s hard to overstate how crucial microglia are to brain health. These humble immune cells quietly patrol the central nervous system, clearing debris, pruning synapses, and maintaining myelin. But ...

A new way to deliver disease-fighting proteins throughout the brain may improve the treatment of Alzheimer's disease and other neurological disorders, according to scientists. By engineering human ...

Proinflammatory cytokines significantly contribute to the initiation and propagation of inflammation and to impaired functional recovery in neuroinflammatory diseases. We identified that microglia ...

Researchers have identified that microglia first help spread Alzheimer’s disease pathology across the brain and then activate to limit its neurodegenerative effects. Researchers from the VIB-KU Leuven ...

This article is based on a poster originally authored by Malika Bsibsi, A. Popalzij, Matteo Zanella, Lieke Geerts, Mark Musters, Inês Ferreira, Stefan Kostense, David F. Fischer and Marijn Vlaming, ...