More than 160 million people across the United States are expected to face winter weather hazards that could cripple their daily lives in coming days, as roads are covered in snow and ice and power lines break from the weight of accumulating ice, according to the National Weather Service’s Weather Prediction Center.

A major winter storm set to slam the U.S. later this week has shifted its path slightly before it arrives on Friday.

Impacts from what could be the most significant storm of winter are expected to begin on Friday, spreading ice, snow and cold across much of the U.S.