DUBAI—Iran has been urgently signaling that it seeks an end to hostilities and resumption of talks over its nuclear programs, sending messages to Israel and the U.S. via Arab intermediaries, Middle Eastern and European officials said.

Smoke and missiles have lit up the skies in Israel and Iran in a fierce standoff triggered by fears over Tehran’s expanding nuclear program. Since June 13, hundreds of military strikes have been exchanged as the two nations remain locked in a conflict that shows no signs of abating.

At least 224 people have been killed in Iran by Israeli strikes, Netanyahu's office said on Monday. The Israel Defense Forces issued a warning to residents in District 3 of Tehran to "immediately leave" ahead of planned strikes there.

The two powers have been exchanging barrages since Israel attacked Iran and killed many of the country’s top military leaders and scientists.

The Iranian regime faces pressure as Israel strikes military targets, with Iranian Americans advocating for the overthrow of what one Iranian American describes as a "paper tiger regime."

The conflict between Israel and Iran has forced many countries in the Middle East to close their airspace, as Israeli jets and Iranian exploding drones and missiles fly over their night skies.

Israel expanded its attacks on Iran on Monday, striking the headquarters of state television after ordering residents to leave part of Tehran, as the fiercest and deadliest confrontation in the history of the Israeli-Iranian conflict entered its fourth day.

Tehran has asked Qatar, Saudi Arabia and Oman to press U.S. President Donald Trump to use his influence on Israel to agree to an immediate ceasefire with Iran in return for Tehran's flexibility in nuclear negotiations,

Iran conflict could open opportunities for Russia to possibly become a power broker to help end the confrontation.