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Q&A: Are mitochondria the key to a healthy brain?
Elizabeth Jonas first got interested in mitochondria by chance. In 1995, she was a postdoctoral researcher at Yale, working ...
C&EN1d
On the Origins of Enzymes: Phosphate-Binding Polypeptides Mediate Phosphoryl Transfer to Synthesize Adenosine Triphosphate - ACS Publications
Reactions involving the transfer of a phosphoryl (−PO32–) group are fundamental to cellular metabolism. These reactions are catalyzed by enzymes, often large and complex, belonging to the ...
Science Daily1d
Scientists discover ‘off switch’ enzyme that could stop heart disease and diabetes
Researchers at UT Arlington have discovered a key enzyme, IDO1, that when blocked, helps immune cells regain their ability to properly process cholesterol—something that breaks down during ...
Scientists Find an “Off Switch” for Cholesterol – And It Could Save Millions
By shutting this “off switch,” immune cells called macrophages regain their ability to soak up cholesterol, potentially ...
ahajournals.org5d
Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation - AHA/ASA Journals
Methods and Results— Cardiomyocyte-specific capn4 knockout mice and their wild-type littermates were injected with lipopolysaccharides. Four hours later, calpain-1 protein and activity were increased ...