Cardinals who will take part in the secret conclave to elect a new Catholic pope began checking into two Vatican hotels on Tuesday, where they will be barred from contact with the outside world as they decide who should succeed Pope Francis.

Cardinals electing a new pope have some fundamental questions to weigh, beyond whether to give the Catholic Church its first Asian or African pope.

Two cardinals, Michael Czerny and Chibly Langlois, sat down with ABC News to discuss the challenges facing the church that the new pope will have to face.