Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Jan 17, 2025 · Yet, SORL1 gets plenty busy in microglia, as well, albeit on a different set of tasks, namely, supporting the lysosome. Previously, Young and colleagues found that while SORL1 …
After Immunotherapy, Amyloid Clearance Comes Down to Microglial …
Mar 14, 2025 · Microglia also took on distinct signatures depending on the extent of amyloid clearance in their neighborhood. For example, in cases of extensive plaque clearance, the cells upregulated …
Protective Microglia Unmasked: They Act Like Regulatory T Cells
Nov 13, 2025 · PU.1-low microglia were rare, making up less than 1 percent of the total. To a “T.” A subtype of regulatory microglia express many of the immunomodulatory receptors typically found on …
TREM2: A Chill Pill for Neurons? | ALZFORUM
Apr 17, 2025 · The microglia then use a cell-specific ATP/ADP hydrolyzing ectoenzyme called CD39 to convert the ATP into AMP, which is then hydrolyzed to adenosine via CD73 receptors expressed by …
A Match Made in Microglia? ApoE and Aβ Click in Lysosomes, Seeding ...
Oct 30, 2024 · The scientists next explored how lysosomal function influenced the development of ApoE aggregates within microglia. Both in a cultured microglial cell line and in human iPSC-derived …
ACE Supercharges Microglia to Shrink Plaques | ALZFORUM
Jul 3, 2025 · Mouse microglia got a genetic tune-up. On 9 June in Nature Aging, researchers led by Warren G. Tourtellotte at Cedars-Sinai Medical Center in Los Angeles reported that expressing …
Part with PILRA, Power Up Microglia? - ALZFORUM
Jul 19, 2024 · Unlike wild-type microglia, PILRA-less iMG barely changed gene expression in response to interferon-γ or lipopolysaccharide (LPS), suggesting they tone down their response to …
Implicated in ARIA: Perivascular Macrophages and Microglia
Aug 16, 2024 · Others in Philadelphia focused on the mechanisms underlying ARIA. Inflammation is emerging as a key culprit, with microglia and perivascular macrophages both playing a role. The …
VHB937 | ALZFORUM
Jun 6, 2025 · VHB937 is a humanized monoclonal antibody to the immune receptor TREM2. TREM2 activation stimulates proliferation and phagocytic function of microglia, which play a central role in …
Lipid-Laden, Sluggish Microglia? Blame Aβ. - ALZFORUM
Sep 6, 2023 · Microglia and macrophages make lipid droplets when stressed by inflammation. Scientists believe the lipids sustain the cells’ metabolic need, enabling them to respond to threats (van …