Astrocytes, the Gatekeepers of Norepinephrine Signaling in the …
Jun 6, 2025 · Norepinephrine modulates neuronal synapses by way of astrocyte adrenergic receptors. The astrocytes release ATP, which converts to adenosine, a neuromodulator that …
Astrocytes Mount Complex Responses to AD. They Change Over …
Dec 5, 2024 · This is an impressive study by Serrano-Pozo, Hyman, Das and colleagues that explores astrocyte transcriptomic molecular programs in aging and Alzheimer’s Disease. …
Alleviating symptoms of neurodegenerative disorders by astrocyte ...
Oct 4, 2023 · The development of an adeno-associated virus (AAV)-mediated strategy for astrocyte-specific overexpression of TMEM164 offers a novel therapeutic target and approach …
In Amyloidosis, EphA4 Goads Astrocytes to Massacre Synapses
Mar 7, 2025 · EphA4 inhibition counteracted both astrocyte reactivity and synaptic engulfment. EphA4 expression rose in both neurons and astrocytes with worsening amyloidosis, but was …
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · Recent studies suggest that when neurons are overwhelmed by oxidative stress, they spew out toxic, peroxidated lipids. Glia then sail in to mop up the spill, containing the oils …
Astrocyte reactivity influences amyloid-β effects on tau
Jun 2, 2023 · Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease. Nat Med. 2023 Jul;29 (7):1775-1781. Epub 2023 May 29 PubMed.
Astrocyte transcriptomic changes along the spatiotemporal …
Dec 6, 2024 · Two different reactive astrocyte clusters showed enrichment for genes that were positively correlated with the degree of p-tau pathology, suggesting that these astrocyte …
GPCR signaling gates astrocyte responsiveness to …
Jun 6, 2025 · Collectively, these papers highlight the critical and diverse roles of astrocytes in mediating the effects of norepinephrine, and related neuromodulators such as tyramine and …
Perineuronal Pockets Prevent Spillage from Synapses - ALZFORUM
Jul 23, 2024 · In wild-type mice, tiny pockets in this perineuronal net give astrocytes access to interneuron synapses, the authors report. The pockets also corralled glutamate and other …
CLU alleviates Alzheimer's disease-relevant processes by …
May 14, 2025 · This article by Lish and colleagues from the Young-Pearse group found that SNPs in CLU modulated astrocyte reactivity to protect neurons from microglia-driven tau …