Update on SORL1: Trafficking is Paramount, in Neurons and …
Jan 17, 2025 · Yet, SORL1 gets plenty busy in microglia, as well, albeit on a different set of tasks, namely, supporting the lysosome. Previously, Young and colleagues found that while SORL1 …
After Immunotherapy, Amyloid Clearance Comes Down to …
Mar 14, 2025 · Microglia also took on distinct signatures depending on the extent of amyloid clearance in their neighborhood. For example, in cases of extensive plaque clearance, the …
Reducing microglial lipid load enhances β amyloid phagocytosis in …
Feb 12, 2025 · Tony Wyss-Coray Stanford University Medical School Andy Tsai Stanford University Posted: 07 Feb 2025 News: Expunging Microglial Lipid Droplets Boosts …
TREM2: A Chill Pill for Neurons? | ALZFORUM
Apr 17, 2025 · The microglia then use a cell-specific ATP/ADP hydrolyzing ectoenzyme called CD39 to convert the ATP into AMP, which is then hydrolyzed to adenosine via CD73 receptors …
Microglia protect against age-associated brain pathologies
Jun 28, 2024 · Both papers agree that the lack of microglia in adult mice results in neurodegeneration, brain calcifications, and myelin abnormalities, phenotypes resembling …
Protective Microglia Unmasked: They Act Like Regulatory T Cells
Nov 13, 2025 · PU.1-low microglia were rare, making up less than 1 percent of the total. To a “T.” A subtype of regulatory microglia express many of the immunomodulatory receptors typically …
Moving Target: New Biology Casts TREM2 as a Shifty Mark
Apr 17, 2025 · For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation by TREM2 agonist antibodies. This …
Part with PILRA, Power Up Microglia? - ALZFORUM
Jul 19, 2024 · Unlike wild-type microglia, PILRA-less iMG barely changed gene expression in response to interferon-γ or lipopolysaccharide (LPS), suggesting they tone down their …
Implicated in ARIA: Perivascular Macrophages and Microglia
Aug 16, 2024 · Others in Philadelphia focused on the mechanisms underlying ARIA. Inflammation is emerging as a key culprit, with microglia and perivascular macrophages both playing a role. …
Expunging Microglial Lipid Droplets Boosts Phagocytosis
Feb 12, 2025 · Wu and colleagues confirmed that cultured-microglia-carrying lipid droplets struggled with phagocytosis, poorly engulfing fluorescently labeled inactivated E. Coli or Aβ. …