Necrosis: When Pancreatic Tissue Begins to Die Pancreatitis isn't just about inflammation; in its most severe form Necrotizing Pancreatitis it becomes a battle for the organ's survival. @vaidyashikhaprakash explains that during a severe acute attack, the blood supply to parts of the pancreas can be cut off. Deprived of oxygen, the pancreatic tissue begins to die or "rot" internally. This dead tissue, known as necrosis, usually starts as sterile (non-infected), but it remains a ticking time bomb